Green Coffee Bean Extract by Labrada BLOWOUT Sale 50-80% Off

Green Coffee Bean Extract by Labrada BLOWOUT Sale 50-80% Off
Brand: Labrada Nutrition
Product Code: 1077933375
Availability: 4
Primary Ingredient: Green Coffee Bean Extract
Primary Use: Fat Loss
Other Use: Antioxidant
Price: $29.99 $5.99
You save: $24.00 (80%)
   - OR -   


Green Coffee Bean Extract

Promotes Fat Loss!*

Natural Anti-Oxidant Support!*

Discontinue Limited Supply

Green Coffee Bean Extract – Natural Fat-Loss Aid & Anti-Oxidant*

If you’re an avid coffee drinker, you may live by the motto: A cup a day keeps the fat away. After all, coffee contains caffeine – and caffeine has a long and trusted reputation as a mild stimulant weight-loss aid.* As reported in 2010, caffeine may be a “support for fat loss” as it has the potential to increase a person's base metabolic rate (the rate at which he or she expends energy at rest) by 4% or 5%.*

However, caffeine isn’t the only ingredient that contributes to coffee’s metabolism-boosting effects.* The actual green (or raw) coffee bean is a powerful fat loss supporting agent in and of itself, containing high amounts of a key substance known as chlorogenic acid.* Sound familiar? Chlorogenic acid has recently been highlighted on the Dr. Oz show based on studies supporting its role in supporting metabolism.* In fact, several reports on both humans and animals suggest that green coffee bean extract (containing chlorogenic acid) holds great potential as a fat loss support.* Harnessing the power of this pure and natural bean, Labrada has introduced Green Coffee Bean Extract Fat-Loss Optimizer.

Another Reason to "Go Green"

Guzzling extra java is certainly a way to temporarily boost energy – but this won’t deliver the fat-loss support you could experience with Green Coffee Bean Extract.* The key is in the green. Raw coffee beans are a major source of chlorogenic acid, but as soon as you put them through the roaster for commercial coffee preparation, you lose most of the "good stuff" – including the chlorogenic acid and other beneficial polyphenolic substances (not to mention the bean’s natural green color).

Green Coffee Bean Extract from Labrada is a natural powder extracted from unroasted coffee beans to ensure maximum strength and effectiveness. Taking Green Coffee Bean Extract in supplement form is also an easy alternative for people who don’t have the desire (or spare change) to drink multiple cups of coffee per day.

Let’s Talk Fat Loss

In contrast to caffeine – which is a stimulant that increases caloric expenditure and stimulates fat burning and weight loss – Green Coffee Bean Extract promotes fat loss via non-stimulant mechanisms.* While these mechanisms are outlined in further detail in our excellent "Digging Deeper into the science section below by Monica Mollica BSc and MSc.

  1. May help slow the release of sugar into the bloodstream (especially after large meals)*
  2. Promoting the activity of your body’s fat-burning enzymes*
  3. Supporting healthy triglyceride (fat) levels, already in normal range*

In a nutshell, Green Coffee Bean Extract may help support lower fasting blood sugar levels and may even help support healthy after-meal blood sugar levels, already in normal range.* This may help guard against extra body fat storage.

In a study analyzing the human consumption of 200 mg of green coffee bean extract per day, average weight loss results were 5.5 pounds (2.5 kg) in 12 weeks. Results were even more significant with higher daily doses; When up to 1,050 mg (350 mg three times daily) of the standardized green coffee bean extract were consumed, along with diet and exercise, some individuals experienced a weight loss of nearly 18 pounds (8 kg) after 22 weeks.* This higher dosage (complemented by diet and exercise), was well tolerated and did not cause any adverse side effects.

Green Coffee Bean Extract has been reported to have antioxidant properties, similar to those of green tea and grape seed extract.* Antioxidants, by nature, provide support against oxidative stress by helping to reduce free radicals in the body.* In this way, Green Coffee Bean Extract is far more than a fat-loss aid – it’s a natural tool to help you feel your best and help promote overall health.*

This article has just barely scratched the surface of what Green Coffee Bean Extract is capable of doing for people of all ages and body types. To learn more about the important role Green Coffee Bean Extract plays in supporting fat loss, please read our "Digging into the Science" section below by Monica Mollica BSc , MSc.*

Digging Deeper Into The Science

In discussions about the health benefits of coffee drinking, the effects of coffee are often confused with those of caffeine. While it is true that many of the effects of coffee are caused by caffeine, coffee also has several interesting and beneficial non-caffeine related effects.

Chlorogenic acid in Green Coffee Bean - a key player

Coffee contains a myriad of biologically active substances, and recent research has identified chlorogenic acid as being one of them 1. Chlorogenic acid is present in highest amounts in the coffee bean and the seeds inside the coffee berry. Green (or raw) coffee is a major source of chlorogenic acid 2. Commercial preparation of coffee destroys a lot of the chlorogenic acid and other beneficial polyphenolic substances, but heavy coffee drinkers may still ingest from 0.5 to 1.0 g chlorogenic acid per day 3. Labrada Green Coffee Bean Extract (details)

Anti-obesity effects of Green Coffee Bean Extract

Several studies in both humans and animals suggest that green coffee bean extract holds great potential as a fat loss support.*

A study investigating the effect of green coffee bean extract on fat accumulation and body weight in mice suggested weight loss with a reduced abdominal (visceral) and hepatic fat content 4.* This effect was attributed to activation of fat metabolism in the liver 4. Another study in mice fed a high-fat diet found that chlorogenic acid not only supported lowered body weight, visceral fat mass and insulin levels already in healthy range, but also supported healthy triglyceride and cholesterol levels, already within healthy range5.* In addition, it was found that chlorogenic acid also promoted adiponectin levels in the blood (more on this below) 5.*

In a study on hamsters fed a high-fat it was found that chlorogenic acid beneficially affected both glucose and fat metabolism, as indicated by supporting healthy levels of fasting blood triglycerides, free fatty acids, total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glucose (FSG), and insulin 6, already within healthy range.* This study also suggested a reduction in live fat content6.*

In humans, supplementation of 200 mg green coffee extract per day may support weight loss 7.* Higher daily doses up to 1050 mg (350 mg three times daily) of the standardized green coffee bean extract (Svetol®) may support weight loss of up to 8 kg after 22 weeks, for individuals who also adhered to diet and exercise advice 7.* The higher dose was well tolerated and did not cause any adverse effects 7.*

How does it work?

In contrast to caffeine, which is a stimulant that increases caloric expenditure 11-14 and stimulates fat burning 13,15 and thereby weight loss 16green coffee bean supports fat loss via non-stimulant mechanisms.* First, green coffee bean slows down the absorption of glucose from the small intestine 17 and lowers after-meal blood glucose levels; the importance of this can be illustrated with the well documented effects seen with low glycemic index foods (enhanced fat burning, increased satiety and fat loss 18-21), which also slow down the absorption of glucose and lower blood glucose levels 22.*

Second, green coffee bean may work to inhibit carbohydrate digesting enzymes 23-26 and the actual absorption process itself 23,27.* This would mean that less glucose gets taken up by the body, and thereby less calories.*

Third, green coffee bean also shifts the site of glucose absorption to more distal parts of the intestine 17, which may support the secretion of the gut hormone GLP-1 (glucagon-like peptide 1). *28,29 This is an interesting effect in that GLP-1 currently is generating much scientific attention due to its involvement in satiety control, glucose homeostasis, and the cardiovascular system. The possible GLP-1 weight loss support has been attributed to a reduction in food intake and slowing of gastric emptying 33.*

Fourth, chlorogenic acid in green coffee bean helps inhibit fat synthesizing enzymes, while supporting the activity of fat burning enzymes 5.*

Finally, as mentioned above, green coffee bean may support blood levels of adiponectin 5,34, a hormone that is secreted from fat cells.* Adiponectin promotes fat burning 35 and also supports insulin sensitivity, and supports healthy blood glucose (blood sugar), already within normal range36-38.*

Supports healthy after-meal blood glucose levels already in normal range*

Another major effect of green coffee bean is its ability to support fasting blood glucose levels 34, and possibly support healthy after-meal blood glucose levels, already in normal range39,40.*

How effective is green coffee bean extract? In mice, green coffee bean extract was suggested to dampen the elevation of blood glucose by 43% after a heavy meal 39.* A notable study in humans tested different dosages of a standardized green coffee bean extract containing 50% chlorogenic acid 40. The subjects were given doses from 100 mg up to 400 mg and then ingested 100 g glucose (which is a standard method of testing of after-meal blood sugar elevations). It was surmised to support healthy after-meal blood glucose levels, already in normal range.* In the group of human subjects who took the 400 mg dose, there was up to a 24% drop in just 30 minutes after glucose ingestion, and a 32% drop after 2 hours 40. *

What determines your blood sugar levels?

While the amount of carbohydrates that you eat, has a significant effect on your after-meal blood sugar levels, this isn't the whole picture. There is an enzyme in the liver called glucose-6-phosphatase (G6P), which is a big player in the blood glucose equation. G6P releases glucose from stored glycogen in the liver into the bloodstream, and also converts protein to glucose 64. Among physically inactive people and those who tend to store body fat around the waist, the activity of G6P is elevated 65-71. Stress also greatly ramps up G6P 66,72.

It is here that chlorogenic acid may help; apart from inhibiting and slowing down the absorption of glucose, chlorogenic acid may also help reduce the activity of G6P 73,74, which may help support healthy after-meal glucose levels already within normal range.*



60 Capsules  
Supplement Facts
Serving Size Capsules
Servings Per Container 30
Amount Per Serving % DV**
Green Coffee Bean Extract 1050mg
** Percent Daily Values are based on a 2,000 calorie diet
† Daily Value (DV) not established
Other Ingredients:
Gelatin, Maltodextrin, Magnesium Stearate, Silica, Sodium Copper Chlorophyllin, Titanium Dioxide.


Directions For Green Coffee Bean Extract : Consume 2 capsules daily with food or as recommended by your health care professional.

Warnings: If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use. Keep Out Of Reach Of Children. Protect from heat, light and moisture. Store at 15-30C or 59-86F.


  1. Farah A, Monteiro M, Donangelo CM, Lafay S. Chlorogenic acids from green coffee extract are highly bioavailable in humans. The Journal of nutrition. Dec 2008;138(12):2309-2315.
  2. Farah A, Donangelo CM. Phenolic compounds in coffee. Braz J Plant Physiol. 2006;18:23–36.
  3. Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. The Journal of nutrition. Jan 2001;131(1):66-71.
  4. Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC complementary and alternative medicine. 2006;6:9.
  5. Cho AS, Jeon SM, Kim MJ, et al. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Mar 2010;48(3):937-943.
  6. Li SY, Chang CQ, Ma FY, Yu CL. Modulating effects of chlorogenic acid on lipids and glucose metabolism and expression of hepatic peroxisome proliferator-activated receptor-alpha in golden hamsters fed on high fat diet. Biomedical and environmental sciences : BES. Apr 2009;22(2):122-129.
  7. Onakpoya I, Terry R, Ernst E. The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. Gastroenterology research and practice. 2011;2011.
  8. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. The Journal of international medical research. Sep-Oct 2000;28(5):229-233.
  9. Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. The Journal of international medical research. Nov-Dec 2007;35(6):900-908.
  10. Dellaibera B, Lemaire S, Lafay S. Svetol, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie. 2006;4:194–197.
  11. Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. The American journal of clinical nutrition. Jan 1989;49(1):44-50.
  12. Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition. May 1990;51(5):759-767.
  13. Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jequier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. The American journal of clinical nutrition. May 1980;33(5):989-997.
  14. Bracco D, Ferrarra JM, Arnaud MJ, Jequier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. The American journal of physiology. Oct 1995;269(4 Pt 1):E671-678.
  15. Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807.
  16. Lopez-Garcia E, van Dam RM, Rajpathak S, Willett WC, Manson JE, Hu FB. Changes in caffeine intake and long-term weight change in men and women. The American journal of clinical nutrition. Mar 2006;83(3):674-680.
  17. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. The American journal of clinical nutrition. Oct 2003;78(4):728-733.
  18. Brand-Miller JC, Holt SH, Pawlak DB, McMillan J. Glycemic index and obesity. The American journal of clinical nutrition. Jul 2002;76(1):281S-285S.
  19. Lopes da Silva MV, de Cassia Goncalves Alfenas R. Effect of the glycemic index on lipid oxidation and body composition. Nutricion hospitalaria : organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral. Jan-Feb 2011;26(1):48-55.
  20. Thomas DE, Elliott EJ, Baur L. Low glycaemic index or low glycaemic load diets for overweight and obesity. Cochrane Database Syst Rev. 2007(3):CD005105.
  21. Stevenson E, Williams C, Nute M, Humphrey L, Witard O. Influence of the glycaemic index of an evening meal on substrate oxidation following breakfast and during exercise the next day in healthy women. European journal of clinical nutrition. May 2008;62(5):608-616.
  22. Jenkins DJ, Wolever TM, Taylor RH, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. The American journal of clinical nutrition. Mar 1981;34(3):362-366.
  23. Ishikawa A, Yamashita H, Hiemori M, et al. Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum. Journal of nutritional science and vitaminology. Apr 2007;53(2):166-173.
  24. Iwai K, Kim MY, Onodera A, Matsue H. Alpha-glucosidase inhibitory and antihyperglycemic effects of polyphenols in the fruit of Viburnum dilatatum Thunb. Journal of agricultural and food chemistry. Jun 28 2006;54(13):4588-4592.
  25. Funke I, Melzig MF. Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay. Die Pharmazie. Oct 2005;60(10):796-797.
  26. Narita Y, Inouye K. Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II. Journal of agricultural and food chemistry. Oct 14 2009;57(19):9218-9225.
  27. Welsch CA, Lachance PA, Wasserman BP. Dietary phenolic compounds: inhibition of Na+-dependent D-glucose uptake in rat intestinal brush border membrane vesicles. The Journal of nutrition. Nov 1989;119(11):1698-1704.
  28. Morgan LM, Flatt PR, Marks V. Nutrient regulation of the enteroinsular axis and insulin secretion. Nutrition research reviews. Jan 1988;1(1):79-97.
  29. Ranganath L, Norris F, Morgan L, Wright J, Marks V. Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycaemic effect. Diabetic medicine : a journal of the British Diabetic Association. Feb 1998;15(2):120-124.
  30. McCarty MF. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. Medical hypotheses. 2005;64(4):848-853.
  31. Vilsboll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ. 2012;344:d7771.
  32. Papazafiropoulou A, Pappas SI, Papadogiannis D, Tentolouris N. Cardiovascular effects of glucagon-like peptide 1. Mini reviews in medicinal chemistry. Jan 2011;11(1):97-105.
  33. Verges B, Bonnard C, Renard E. Beyond glucose lowering: glucagon-like peptide-1 receptor agonists, body weight and the cardiovascular system. Diabetes & metabolism. Dec 2011;37(6):477-488.
  34. Zhang LT, Chang CQ, Liu Y, Chen ZM. [Effect of chlorogenic acid on disordered glucose and lipid metabolism in db/db mice and its mechanism]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. Jun 2011;33(3):281-286.
  35. Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes. Sep 2006;55(9):2562-2570.
  36. Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. European journal of endocrinology / European Federation of Endocrine Societies. Mar 2003;148(3):293-300.
  37. Nedvidkova J, Smitka K, Kopsky V, Hainer V. Adiponectin, an adipocyte-derived protein. Physiological research / Academia Scientiarum Bohemoslovaca. 2005;54(2):133-140.
  38. Ravussin E. Adiponectin enhances insulin action by decreasing ectopic fat deposition. The pharmacogenomics journal. 2002;2(1):4-7.
  39. Murase T, Misawa K, Minegishi Y, et al. Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice. American journal of physiology. Endocrinology and metabolism. Jan 2011;300(1):E122-133.
  40. Nagendran MV. Effect of Green Coffee Bean Extract (GCE), High in Chlorogenic Acids, on Glucose Metabolism. 29th Annual Scientific Meeting of the Obesity Sociaty. Orlando, Florida,: Poster presentation number: 45-LB-P; 2011.
  41. Lloyd-Jones DM, Hong Y, Labarthe D, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation. Feb 2 2010;121(4):586-613.
  42. Release CP. Number of Americans with Diabetes Rises to Nearly 26 Million. More than a third of adults estimated to have prediabetes. January 13, 2011. Available at: Accessed April 7th, 2012.
  43. Kato M, Noda M, Suga H, Matsumoto M, Kanazawa Y. Fasting plasma glucose and incidence of diabetes --- implication for the threshold for impaired fasting glucose: results from the population-based Omiya MA cohort study. Journal of atherosclerosis and thrombosis. 2009;16(6):857-861.
  44. Yamagata H, Kiyohara Y, Nakamura S, et al. Impact of fasting plasma glucose levels on gastric cancer incidence in a general Japanese population: the Hisayama study. Diabetes care. Apr 2005;28(4):789-794.
  45. Gerstein HC, Pais P, Pogue J, Yusuf S. Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study. Journal of the American College of Cardiology. Mar 1999;33(3):612-619.
  46. Bjornholt JV, Erikssen G, Aaser E, et al. Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men. Diabetes care. Jan 1999;22(1):45-49.
  47. Balkau B, Shipley M, Jarrett RJ, et al. High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study. Diabetes care. Mar 1998;21(3):360-367.
  48. Monnier L, Colette C. Glycemic variability: should we and can we prevent it? Diabetes care. Feb 2008;31 Suppl 2:S150-154.
  49. Monnier L, Colette C, Owens DR. Glycemic variability: the third component of the dysglycemia in diabetes. Is it important? How to measure it? Journal of diabetes science and technology. Nov 2008;2(6):1094-1100.
  50. Temelkova-Kurktschiev TS, Koehler C, Henkel E, Leonhardt W, Fuecker K, Hanefeld M. Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level. Diabetes care. Dec 2000;23(12):1830-1834.
  51. Hanefeld M, Temelkova-Kurktschiev T. The postprandial state and the risk of atherosclerosis. Diabetic medicine : a journal of the British Diabetic Association. Aug 1997;14 Suppl 3:S6-11.
  52. Levitan EB, Song Y, Ford ES, Liu S. Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Archives of internal medicine. Oct 25 2004;164(19):2147-2155.
  53. Natella F, Scaccini C. Role of coffee in modulation of diabetes risk. Nutrition reviews. Apr 2012;70(4):207-217.
  54. van Dijk AE, Olthof MR, Meeuse JC, Seebus E, Heine RJ, van Dam RM. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes care. Jun 2009;32(6):1023-1025.
  55. Ong KW, Hsu A, Tan BK. Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes. PloS one. 2012;7(3):e32718.
  56. van Dam RM. Coffee and type 2 diabetes: from beans to beta-cells. Nutrition, metabolism, and cardiovascular diseases : NMCD. Jan 2006;16(1):69-77.
  57. Battram DS, Arthur R, Weekes A, Graham TE. The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men. The Journal of nutrition. May 2006;136(5):1276-1280.
  58. Naismith DJ, Akinyanju PA, Szanto S, Yudkin J. The effect, in volunteers, of coffee and decaffeinated coffee on blood glucose, insulin, plasma lipids and some factors involved in blood clotting. Nutrition and metabolism. 1970;12(3):144-151.
  59. Keijzers GB, De Galan BE, Tack CJ, Smits P. Caffeine can decrease insulin sensitivity in humans. Diabetes care. Feb 2002;25(2):364-369.
  60. Greer F, Hudson R, Ross R, Graham T. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes. Oct 2001;50(10):2349-2354.
  61. Pizziol A, Tikhonoff V, Paleari CD, et al. Effects of caffeine on glucose tolerance: a placebo-controlled study. European journal of clinical nutrition. Nov 1998;52(11):846-849.
  62. Greenberg JA, Boozer CN, Geliebter A. Coffee, diabetes, and weight control. The American journal of clinical nutrition. Oct 2006;84(4):682-693.
  63. Mithieux G. New knowledge regarding glucose-6 phosphatase gene and protein and their roles in the regulation of glucose metabolism. European journal of endocrinology / European Federation of Endocrine Societies. Feb 1997;136(2):137-145.
  64. Argaud D, Kirby TL, Newgard CB, Lange AJ. Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. The Journal of biological chemistry. May 9 1997;272(19):12854-12861.
  65. Im SS, Kim MY, Kwon SK, et al. Peroxisome proliferator-activated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice. The Journal of biological chemistry. Jan 14 2011;286(2):1157-1164.
  66. van de Werve G, Lange A, Newgard C, Mechin MC, Li Y, Berteloot A. New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. European journal of biochemistry / FEBS. Mar 2000;267(6):1533-1549.
  67. Lam TK, Carpentier A, Lewis GF, van de Werve G, Fantus IG, Giacca A. Mechanisms of the free fatty acid-induced increase in hepatic glucose production. American journal of physiology. Endocrinology and metabolism. May 2003;284(5):E863-873.
  68. Lam TK, van de Werve G, Giacca A. Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. American journal of physiology. Endocrinology and metabolism. Feb 2003;284(2):E281-290.
  69. Goodridge AG. Dietary regulation of gene expression: enzymes involved in carbohydrate and lipid metabolism. Annual review of nutrition. 1987;7:157-185.
  70. Massillon D, Barzilai N, Hawkins M, Prus-Wertheimer D, Rossetti L. Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion. Diabetes. Jan 1997;46(1):153-157.
  71. Xu C, Chakravarty K, Kong X, et al. Several transcription factors are recruited to the glucose-6-phosphatase gene promoter in response to palmitate in rat hepatocytes and H4IIE cells. The Journal of nutrition. Mar 2007;137(3):554-559.
  72. Lange AJ, Argaud D, el-Maghrabi MR, Pan W, Maitra SR, Pilkis SJ. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Biochemical and biophysical research communications. May 30 1994;201(1):302-309.
  73. Henry-Vitrac C, Ibarra A, Roller M, Merillon JM, Vitrac X. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. Journal of agricultural and food chemistry. Apr 14 2010;58(7):4141-4144.
  74. Andrade-Cetto A, Vazquez RC. Gluconeogenesis inhibition and phytochemical composition of two Cecropia species. Journal of ethnopharmacology. Jul 6 2010;130(1):93-97.
  75. Ryden L, Standl E, Bartnik M, et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). European heart journal. Jan 2007;28(1):88-136.

Write a review

Your Name:

Your Review: Note: HTML is not translated!

Rating: Bad           Good

Enter the code in the box below:

© 1997-2015   |   Body And Fitness Group; Cheyenne WY 82001