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Ursolic Acid 120 cap by Labrada

Ursolic Acid 120 cap by Labrada
Brand:Labrada Nutrition
Product Code: 710779333741 DS
Availability: 40
Primary Ingredient: Ursolic Acid
Primary Use: Fat Loss
Other Use: Lean Muscle
Price: $25.99$14.99
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Labrada

Ursolic Acid 120 Caps 

Lean Muscle Promoter!*

Supports Fat Loss and Lean Muscle!*

Supports Fat Loss, Lean Muscle, & Cardiovascular Health!*
Ursolic acid counteracts muscle breakdown during catabolic conditions like fasting and dieting and can also help to reduce body fat, and lower sugar and lipid levels in blood.*

Fighting Fat While Sparing Precious Muscle

When it comes to getting in shape, do you ever find yourself in a “catch 22”? Coined in the early 1960s, this expression refers to a no-win situation – one where solving one part of a problem only creates another. Picture this as an example: You clean out the junk in your diet, you begin hitting the gym, and you lose 15 pounds. Great! Mission accomplished, right? Maybe not. In your effort to lose unwanted weight, you’ve also lost a precious commodity – muscle. Your waistline may be smaller, but your body is soft, lacking definition. You’ve solved one part of the problem (the number on your scale), only to encounter another (loss of muscle tone). This is the reality for many – having to choose between fat loss and muscle growth. If only there was a way to achieve both…

Trust the Old Adage

As it turns out, an apple a day does more than keep the doctor away. A naturally occurring ingredient found in apple peels (ursolic acid) has actually been suggested to support fat loss and muscle growth… and not just one or the other. People who are especially concerned about sparing – and ultimately building – muscle can be confident knowing that Labrada’s new Ursolic Acid Lean Muscle Optimizer has their goals for a lean, defined body in mind.* That’s because ursolic acid has been suggested to affect molecular pathways that could actually prevent muscle loss and weakness.* In some studies involving both humans and mice, ursolic acid was surmised to help counteract the catabolic effects of fasting/dieting.* Meanwhile, in studies with just mice, this natural ingredient was surmised to help protect against a decrease in muscle mass.* In fact, when ursolic acid was added to the food of normal, non-fasted mice, it supported muscle growth.*

While ursolic acid as a dietary supplement has only recently come into the spotlight, early findings are extremely promising and human clinical trials continue. Because plants containing ursolic acid have been used in herbalism for centuries, you can be confident this ingredient is natural, safe, and effective.*

Fat Loss Anyone?

In the previously mentioned study where mice experienced muscle growth when given ursolic acid, it was also found that the mice became leaner and supported healthy blood levels of glucose, cholesterol, and triglycerides, already in normal range* This, again, is that coveted combination that many of us strive for – muscle growth and fat loss rolled into one. Supplementing with Labrada’s Ursolic Acid may help make all the difference.* As further suggested in studies, mice that were fed ursolic acid and a high-fat diet had significantly lower body weights and abdominal (visceral) adiposity compared to mice on the same diet but without the ursolic acid supplement.* Diet and activity levels were the same for both groups; the only “edge” was the ursolic acid.* The question then remains: What could Ursolic Acid do for you?

It All Comes Back to Supporting Health

Labrada’s Ursolic Acid hasn’t just been designed to help support your goals. It may even help support cardiovascular health, making it a beneficial supplement for dieters and athletes of all ages.* Because Ursolic Acid can help support healthy body composition, it provides nutritional support that may be beneficial for promoting weight loss.* It also plays a role in bone and joint health.*

WANT TO DIG DEEPER INTO THE SCIENCE?

While studies continue on ursolic acid and its role in fat loss and muscle sparing, you can view some of the current research by Monica Mollica BSc , MSc. below.

Ursolic acid is a newly discovered substance, which is a component of apple peels. Ursolic acid has generated a lot of scientific interest lately, because it has been found to affect molecular pathways that may help prevent muscle loss and weakness and promote healthy body composition.*

What is it?

Ursolic acid, also known as urson, prunol, micromerol, and malol, is a pentacyclic triterpenoid compound which naturally occurs in a large number of vegetarian foods, herbs, and other plants, including apples and rosemary 1,2.

Anti-catabolic - Preservation of Muscle Mass

The anti-catabolic effect of ursolic acid was recently surmised by a study that looked at what happens to gene activity in muscles during catabolic situations like fasting 3. It was found that fasting in both people and mice changes gene expression in many genes. These gene expression changes were then compared to those seen in muscle fibers that had been exposed to a wide array of bioactive molecules. Of all the tested bioactive molecules, ursolic acid turned out to be a unique substance that induced a gene expression pattern that reduced the catabolic effects of fasting.*

Next, ursolic acid was given to fasted mice, and found to reduce muscle catabolism.* When ursolic acid was added to the food of normal (non-fasted) mice for five weeks, their muscles grew.* These effects were mediated by enhanced insulin signaling in muscle and counteracting of the gene expression pattern causing muscle catabolism.*

Fat loss

In the same study 3, it was further suggested that mice given ursolic acid also became leaner and supported healthy body composition.*

Another study specifically evaluated ursolic acid for its effects on blood glucose, lipids, and abdominal fat deposition in mice. Mice supplemented with ursolic acid had significantly decreased body weights, abdominal (visceral) adiposity, and supported healthy levels of blood glucose and plasma lipids that were already in healthy range.* Also, a significant increase was observed in levels of leptin with a decrease in ghrelin 4.*

Ghrelin is a hormone secreted in the stomach. It has an orexigenic (appetite increasing) effect through its action on the hypothalamic appetite-regulating pathways 5-8. It also promotes adipose tissue accumulation6.*

Leptin, a hormone secreted from fat cells, has wide ranging effects in the body 9. Among all, it plays a key role in regulating energy intake and energy expenditure 9-12

Thus, the increase in leptin and decrease in ghrelin levels may have contributed to these ursolic acid supported fat loss effects.* Ursolic acid also has been suggested to increase liberation of fatty acids from body fat stores 13,14, and inhibit fat absorption by reducing the activity of pancreatic lipase (an enzyme that is necessary for fat absorption)14.* Thus, ursolic acid can help support healthy body composition via several complementary mechanisms.*

Supports healthy blood lipid profile and promotes blood sugar control*

The ability of ursolic acid to support healthy blood sugar already in normal range, was further surmised in another study, which also found that ursolic may help support healthy levels of total blood cholesterol and LDL (the bad cholesterol) already within normal range, and support levels of HDL (the good cholesterol), and stimulates liver glycogen synthesis.* 15

May help support a healthy heart*

The walls of large arteries, when activated, recruit circulating monocytes (a type of white blood cell)16. A common condition that affects monocytes in a negative way is high blood sugar 17, which can be caused by a high carbohydrate diet and physical inactivity. High blood sugar levels cause a low grade inflammatory state, and monocytes are important in orchestrating these effects 17. In light of this, it is interesting that ursolic acid may help support healthy monocyte function18.*

Ursolic acid may also beneficially affect endothelial cells and thereby promote cardiovascular health via other mechanisms.* One of those is via an up-regulation of eNOS expression in endothelial cells and increase in bioactive vascular nitric oxide, and parallel downregulation of eNOS-dependent production of free radicals in human endothelial cells 19.*

eNOS stands for endothelial nitric oxide synthase, and is the enzyme in blood vessels that produces nitric oxide. In the body, nitric oxide is an important cellular signaling molecule. Nitric oxide has gained status as one of the most important signaling molecules in the cardiovascular system, and is regarded to be a ubiquitous mediator of cardioprotection 20. Supporting nitric oxide levels and activities in the heart and blood vessels may help support cardiovascular health.* Thus, ursolic acid may hold great potential in being a natural dietary compound that promotes eNOS actvity and nitric oxide levels.*

Promote bone and joint health*

There has been growing interest in supplements that support healthy bone mass. It has been suggested that ursolic acid has anabolic effects on the skeleton by supporting osteoblast differentiation, bone mineralization to promote healthy bone formation 24.*

Safety

Ursolic acid is a natural dietary substance that only recently has started to generate scientific interest. While most of the studies on ursolic acid have been made in mice and cell cultures, plants containing ursolic acid have been used in herbalism for centuries 1. It has been established that ursolic acid is non-toxic 1, so we can count on seeing products being developed with ursolic acid as the active ingredient for different supplements in the near future.*

Bottom line

The presence of ursolic acid in apple peels and many edible plants contributes to their overall health benefits. Ursolic acid not only helps reduce catabolism during conditions like fasting and dieting, but may also help to reduce body fat, and support healthy sugar and lipid levels in blood, when already in normal range.* These effects may be beneficial for promoting healthy body composition.*

Ursolic acid is generating a lot of scientific interest as being a novel and bioactive molecule for supplement use 26-31. With all the recent studies on ursolic acids, the old cliché "an apple a day keeps the doctor away" could more specifically be restated as "an apple a day helps keep muscle loss and body flab away".*



120 Capsules  
Supplement Facts
Serving Size Capsules
Servings Per Container 30
 
Amount Per Serving% DV**
 
Ursolic Acid150mg
(From Rosemary Leaf Extract)
 
** Percent Daily Values are based on a 2,000 calorie diet
† Daily Value (DV) not established
Other Ingredients:
Maltodextrin, Gelatin, Silica, Magnesium Stearate, Titanium Dioxide, Sodium Copper Chlorophyllin.

 

Directions For Ursolic Acid: Take 3 capsules 3 times per day with food.

Warnings: This product is only intended to be consumed by healthy adults 18 years of age or older. Before using this product consult with your physician if you are using any prescription or over the counter medicine, if you are unaware of your current medical condition or if you have any pre-existing medical condition. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Store in a cool, dry place with lid tightly closed. Keep Out Of Reach Of Children.

Ursolic acid is a newly discovered substance, which is a component of apple peels. Ursolic acid has generated a lot of scientific interest lately, because it has been found to affect molecular pathways that could prevent muscle loss and weakness, promote fat loss, and have a beneficial effect on multiple chronic diseases.*

What is it?

Ursolic acid, also known as urson, prunol, micromerol, and malol, is a pentacyclic triterpenoid compound which naturally occurs in a large number of vegetarian foods, medicinal herbs, and other plants, including apples and rosemary.1,2

Anti-catabolic - Preservation of Muscle Mass

The anti-catabolic effect of ursolic acid was recently discovered in a study that looked at what happens to gene activity in muscles during catabolic situations like fasting.3 It was found that fasting in both people and mice changes gene expression in many genes. These gene expression changes were then compared to those seen in muscle fibers that had been exposed to a wide array of bioactive molecules. Of all the tested bioactive molecules, ursolic acid turned out to be a unique substance that induced a gene expression pattern that counteracted the catabolic effects of fasting.

Next, ursolic acid was given to fasted mice, and found to protect against muscle atrophy. When ursolic acid was added to the food of normal (non-fasted) mice for five weeks, their muscles grew. These effects were mediated by enhanced insulin signaling in muscle and counteracting of the gene expression pattern causing muscle atrophy.

Fat loss

In the same study,3 it was further shown that mice given ursolic acid also became leaner and had lower blood levels of glucose, cholesterol and triglycerides.

Another study specifically evaluated ursolic acid for its effects on blood glucose, lipids, and abdominal fat deposition in mice fed a high-fat diet. Mice supplemented with ursolic acid and fed a high-fat diet had significantly decreased body weights, abdominal (visceral) adiposity, and levels of blood glucose and plasma lipids compared to mice on the same diet but without the ursolic acid supplement. Also, a significant increase was observed in levels of leptin with a decrease in ghrelin.4

Ghrelin is a hormone secreted in the stomach. It has an orexigenic (appetite increasing) effect through its action on the hypothalamic appetite-regulating pathway.5-8 It also increases adipose tissue accumulation and has a diabetogenic effect on the liver and pancreas.6

Leptin, a hormone secreted from fat cells, has wide ranging effects in the body.9 Among all, it plays a key role in regulating energy intake and energy expenditure.9-12

Thus, the increase in leptin and decrease in ghrelin levels most likely contributed to these ursolic acid induced anti-obesity effects. Ursolic acid also has been shown to increase liberation of fatty acids from body fat stores,13,14 and inhibit fat absorption by reducing the activity of pancreatic lipase (an enzyme that is necessary for fat absorption).14 Thus, ursolic acid can help to fight off excess body fat via several complementary mechanisms.*

Improved Blood Lipid Profile and Blood Sugar Control

The ability of ursolic acid to lower blood sugar was further demonstrated in another study, which also found that ursolic acid significantly lowers levels of total blood cholesterol and LDL (the bad cholesterol), increases HDL (the good cholesterol), and stimulates liver glycogen synthesis.15 This study concluded that ursolic acid may be useful for people at risk of developing diabetes and associated cardiovascular complications by improving plasma glucose levels and lipid profile, as well as by promoting liver glycogen deposition.

Anti-Atherogenic and Cardio Protective

The walls of large arteries, when activated, recruit circulating monocytes (a type of white blood cell).16 This in turn contributes to chronic inflammation and the development and progression of atherosclerosis.16 A common condition that affects monocytes in a negative way is high blood sugar (hyperglycemia),17 which can be caused by a high carbohydrate diet and physical inactivity. High blood sugar levels cause a low grade inflammatory state, and monocytes are important in orchestrating these effects.17 In light of this, it is interesting that ursolic acid is a potent inhibitor of monocyte dysfunction and the development of an inflammatory state, and has anti-atherogenic properties.18

Ursolic acid also beneficially affects endothelial cells and thereby promotes cardiovascular health via other mechanisms. One of those is via an up-regulation of eNOS expression in endothelial cells and increase in bioactive vascular nitric oxide, and parallel downregulation of eNOS-dependent production of free radicals in human endothelial cells.19

eNOS stands for endothelial nitric oxide synthase, and is the enzyme in blood vessels that produces nitric oxide. In the body, nitric oxide is an important cellular signaling molecule. Nitric oxide has gained status as one of the most important signaling molecules in the cardiovascular system, and is regarded to be a ubiquitous mediator of cardioprotection.20 The origin of many cardiovascular diseases is associated with reduced nitric oxide production and availability and/or increased endothelial eNOS-dependent free radical formation.20-22 Therefore, restoring and/or increasing adequate nitric oxide levels and activities in the heart and blood vessels is a promising therapeutic intervention with a high potential for effective prevention and/or treatment of cardiovascular diseases. The fact that several medicines (for ex. nitroglycerine) are active by being precursors to nitric oxide, and that medical drug research is developing medicines that target eNOS to increase its activity,21,23 proves that this mechanism is very important for cardiovascular health. Thus, ursolic acid holds great potential in being a natural dietary compound that increases eNOS actvity and nitric oxide levels.*

Bone and Joint Health

In the field of osteoporosis there has been growing interest in anabolic agents that enhance bone mass and improve bone architecture. It has been demonstrated that ursolic acid has anabolic effects on the skeleton by stimulating osteoblast differentiation, bone mineralization and enhance new bone formation.24

Ursolic acid also has been found to have anti-arthritic effects comparable with that of ibuprofen, but without causing gastric dmage which is a side effect of ibuprofen treatments.25

Safety

Ursolic acid is a natural dietary substance that only recently has started to generate scientific interest. While most of the studies on ursolic acid have been made in mice and cell cultures, medicinal plants containing ursolic acid have been used in folk medicine for centuries.1 It has been established that ursolic acid is non-toxic,1 so we can count on seeing products being developed with ursolic acid as the active ingredient for different health related condition in the near future.

Bottom Line

The presence of ursolic acid in apple peels and many edible plants contributes to their overall health benefits. Ursolic acid not only counteracts muscle breakdown during catabolic conditions like fasting and dieting, but also can help to reduce body fat, and lower sugar and lipid levels in blood. These effects are beneficial for the prevention and/or reduction of the severity of both obesity and diabetes. It is interesting that ursolic acid exerts its potential anti-obesity effects via both hypothalamic and metabolic targets.

In addition, ursolic acid has potent anti-atherogenic and anti-tumor effects that beneficially could influence cardiovascular disease and cancer outcomes. Ursolic acid is generating a lot of scientific interest as being a novel and bioactive molecule for drug discovery.26-31 Currently ursolic acid is in human clinical trials for treating cancer, tumor, and skin wrinkles.26 With all the recent studies on ursolic acids, the old cliché "an apple a day keeps the doctor away" could more specifically be restated as "an apple a day helps keep muscle wasting and body flab away."

References

  1. Liu J. Pharmacology of oleanolic acid and ursolic acid. Journal of ethnopharmacology. Dec 1 1995;49(2):57-68.
  2. Huang MT, Ho CT, Wang ZY, et al. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res. Feb 1 1994;54(3):701-708.
  3. Kunkel SD, Suneja M, Ebert SM, et al. mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell metabolism. Jun 8 2011;13(6):627-638.
  4. Rao VS, de Melo CL, Queiroz MG, et al. Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. Journal of medicinal food. Nov 2011;14(11):1375-1382.
  5. Hashimoto H, Ueta Y. Central effects of ghrelin, a unique peptide, on appetite and fluid/water drinking behavior. Current protein & peptide science. Jun 2011;12(4):280-287.
  6. Scerif M, Goldstone AP, Korbonits M. Ghrelin in obesity and endocrine diseases. Molecular and cellular endocrinology. Jun 20 2011;340(1):15-25.
  7. Castaneda TR, Tong J, Datta R, Culler M, Tschop MH. Ghrelin in the regulation of body weight and metabolism. Frontiers in neuroendocrinology. Jan 2010;31(1):44-60.
  8. De Vriese C, Delporte C. Influence of ghrelin on food intake and energy homeostasis. Current opinion in clinical nutrition and metabolic care. Sep 2007;10(5):615-619.
  9. Mantzoros CS, Magkos F, Brinkoetter M, et al. Leptin in human physiology and pathophysiology. American journal of physiology. Endocrinology and metabolism. Oct 2011;301(4):E567-584.
  10. Brennan AM, Mantzoros CS. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. Nature clinical practice. Endocrinology & metabolism. Jun 2006;2(6):318-327.
  11. Gautron L, Elmquist JK. Sixteen years and counting: an update on leptin in energy balance. The Journal of clinical investigation. Jun 2011;121(6):2087-2093.
  12. Jequier E. Leptin signaling, adiposity, and energy balance. Annals of the New York Academy of Sciences. Jun 2002;967:379-388.
  13. Li Y, Kang Z, Li S, Kong T, Liu X, Sun C. Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes. Molecular nutrition & food research. Nov 2010;54(11):1609-1617.
  14. Kim J, Jang DS, Kim H, Kim JS. Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of Actinidia arguta. Archives of pharmacal research. Jul 2009;32(7):983-987.
  15. Azevedo MF, Camsari C, Sa CM, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C. Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. Phytotherapy research : PTR. Jun 2010;24 Suppl 2:S220-224.
  16. Mestas J, Ley K. Monocyte-endothelial cell interactions in the development of atherosclerosis. Trends in cardiovascular medicine. Aug 2008;18(6):228-232.
  17. Dasu MR, Devaraj S, Zhao L, Hwang DH, Jialal I. High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes. Nov 2008;57(11):3090-3098.
  18. Ullevig SL, Zhao Q, Zamora D, Asmis R. Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. Atherosclerosis. Dec 2011;219(2):409-416.
  19. Steinkamp-Fenske K, Bollinger L, Voller N, et al. Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Atherosclerosis. Nov 2007;195(1):e104-111.
  20. Strijdom H, Chamane N, Lochner A. Nitric oxide in the cardiovascular system: a simple molecule with complex actions. Cardiovascular journal of Africa. Sep-Oct 2009;20(5):303-310.
  21. Pepine CJ. The impact of nitric oxide in cardiovascular medicine: untapped potential utility. The American journal of medicine. May 2009;122(5 Suppl):S10-15.
  22. Zhang Y, Janssens SP, Wingler K, Schmidt HH, Moens AL. Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy. American journal of physiology. Heart and circulatory physiology. Sep 2011;301(3):H634-646.
  23. Braam B, Verhaar MC. Understanding eNOS for pharmacological modulation of endothelial function: a translational view. Current pharmaceutical design. 2007;13(17):1727-1740.
  24. Lee SU, Park SJ, Kwak HB, Oh J, Min YK, Kim SH. Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo. Pharmacological research : the official journal of the Italian Pharmacological Society. Nov-Dec 2008;58(5-6):290-296.
  25. Kang SY, Yoon SY, Roh DH, et al. The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. The Journal of pharmacy and pharmacology. Oct 2008;60(10):1347-1354.
  26. Sultana N. Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. Journal of enzyme inhibition and medicinal chemistry. Oct 2011;26(5):616-642.
  27. Wilkinson K, Boyd JD, Glicksman M, Moore KJ, El Khoury J. A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. The Journal of biological chemistry. Oct 7 2011;286(40):34914-34922.
  28. Meng YQ, Liu D, Bai ZW, Cai LL, Ai HR. [Synthesis and anti-tumor activity of ursolic acid derivatives]. Yao xue xue bao = Acta pharmaceutica Sinica. May 2011;46(5):556-560.
  29. Meng Y, Song Y, Yan Z, Xia Y. Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives. Molecules. Jun 2010;15(6):4033-4040.
  30. Liu J. Oleanolic acid and ursolic acid: research perspectives. Journal of ethnopharmacology. Aug 22 2005;100(1-2):92-94.
  31. Shao JW, Dai YC, Xue JP, Wang JC, Lin FP, Guo YH. In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. European journal of medicinal chemistry. Jul 2011;46(7):2652-2661.

 

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